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With antibiotic resistance on the rise and emergence of superbugs, should antibiotics such as carbapenems and colistin be used by general pediatricians_?
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Diagnostic Dilemma

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Sudden hematemesis with death
Author: Ma Theresa Alianza
Question
8828-C San Mateo St., San Antonio Valley 2, Paranaque City Philippines.

A 17 years old girl presented with headache for 5 days and epigastric pain, fever, hematemesis {1 cup full} and erythematous rash over all 4 limbs for 1 day prior to admission. Three hours prior to admission she had increased headache, epigastric pain with violaceous rash on thighs and increased menstrual flow with difficulty in breathing. There were no cough, colds, diarrhea, dysuria, or increase in sleeping time. She was suspected to have hemolytic uremic syndrome or blood dyscrasias. On examination her systolic blood pressure was 80 mm of Hg, heart rate was 135, min {pulses were not felt}, CRT was 5-6 sec and respiratory rate was 40, min. She had cold clammy skin with ecchymotic rash over lower extremities, pale conjunctivae, sallow sclerae, pale lips, and dry buccal mucosa. On systemic examination she had epigastric tenderness. Other systems were normal. She was non-responsive to fluid resuscitation {PLRS 500ml x 3 doses}. She died before inotropes could be started. Her investigations showed anemia, leukocytosis {WBC 41,400, cumm} with predominance of polymorphs {75 percent}. She had deranged Prothrombin time { More than 60sec} and Partial thromboplastin time { More than 60sec}. She had hypoglycemia {Blood sugar = 32.36mg, dL}, hyponatremia {Serum sodium = 131mmol, L}, hyperkalemia {serum potassium = 5.3mmol, L}, hypocalcemia {Serum calcium = 7.08mg, dL} with raised blood urea nitrogen {20.17mg, dL}, increased serum creatinine {2.36mg, dL} with BUN: creatinine ratio=8.5 suggestive of intrinsic renal failure. Her urine showed trace sugar, 3plus proteins, with presence of urine hemoglobin.

 
Answer For Question
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Author:-zohdi alhanouty
>>> DIC and multiple organ failure due to meningococcemia

Author:-Binayak
>>> kaowasaki disease involving kidney

Author:-makramgs nagy
>>> D.D.should include many in many cases as our case there is shock mostly septic shock,DIC with prolonged PT and PTT ,and ARF.Is it meningiococcal septicemia,complicated thromocytopenic purpura with ICH and multiorgans failure or acute haemoragic fever.

Author:-PRITI SINGHAI
>>> SEPTIC SHOCK with DIC

Author:-girish gopalakrishnan
>>> dengue hemorrhagic fever with unusual bleed

Author:-Ahmet Aslan
>>> Staphylococcic Toxic Shock Syndrome

Author:-jayanthi
>>> acute on chronic liver disease

Author:-vivek chetal
>>> urine hemoglobin- hemoglobinuria suggests intravascular hemolysis _?_?DIC due to sepsis , Black Water Fever secondary to Severe Malaria is also a possiblity. Second i am not sure if the amount of bolus fluids{ 1.5L } was adequate even if septic shock was the etiology, i would presume her dose would have been 2.5 L !! So is it ok to call it fluid refractory_?

Author:-drRanjith kumar
>>> dengue shock syndrome, meningococal septicemia.

Author:-SUJATA GUPTA
>>> meningococcimia

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