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| Aspirin (acetyl salicylic acid) |
It is white crystalline substance with acidic taste. It is commonly used as an antipyretic and analgesic
Route : Ingestion
Fatal dose : 5 to 10 gms
Fatal Period : few minutes to several hours
Clinical picture : Poisoning usually occurs due to idiosyncrasy or consumption of excessive dose
• Irritation of stomach, nausea , vomiting, hematemesis, malena
• Skin rash
• Oedema of face and eyelids
• cyanosis
• giddiness
• pyrexia
• buzzing in ears, vertigo, deafness
• drowsiness
• hypoprothrombinemia
• acidosis, ketosis
• presence of albumin and glucose in urine
Reye’s syndrome: it is sometimes seen in children below 15 years on consumption of aspirin. The main features are acute onset hepatic failure and encephalopathy with residual neurologic manifestations
Treatment : • Emetics
• Gastric lavage with sodium bicarbonate
• Forced alkaline diuresis
• Peritoneal dialysis and hemodialysis
• Vit K to check bleeding
• Symptomatic
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